CordenPharma International and pHLIP, Inc. announced a strategic alliance to collaborate in developing and commercializing the pHLIP-LNP targeted delivery platform for RNA-based and genetic therapeutics.
The alliance will combine CordenPharma’s proprietary Lipid NanoParticle (LNP) technology and GMP manufacturing expertise with pHLIP’s proprietary pH (Low) Insertion Peptide (pHLIP®) targeted delivery technology and drug development expertise to formulate (pHLIP®) coated LNPs for use by biopharmaceutical companies seeking to deliver mRNA-based and gene therapy payloads.
Such payloads can be used to treat cancer, inflammation, and genetic diseases, or employ mRNA strategies for vaccination. The companies believe that their novel pHLIP-LNP platform will greatly enhance the commercial viability and success of many pioneering RNA, DNA and CRISPR therapies.
The alliance will also enable CordenPharma and pHLIP to collaborate in developing and manufacturing small molecule drug payloads directly conjugated with (pHLIP®) peptides for biopharmaceutical companies seeking to selectively target their small molecular payloads into cells in acidic diseased tissues.
CordenPharma serves as the CDMO supplier in the GMP manufacture of pHLIP® peptides and (pHLIP®) drug conjugates, and the new alliance further builds upon their collaborative efforts in this important field.
Also, prior research has shown that pHLIP® can target a variety of nanoparticles, including lipid nanoparticles, to tumors, where it promotes more efficient intracellular delivery of encapsulated payloads. pHLIP® peptides position LNPs close to the membrane lipid bilayer of a targeted cell, promoting fusion, lipid exchange and cytoplasmic cargo delivery.
The range of potential therapeutic cargoes is large, and includes the important directions enabled by RNA delivery. CordenPharma's expertise in formulating and manufacturing LNPs and pHLIP® peptides makes them our ideal partner for this important venture. The University of Rhode Island will continue to be our partner in the development of the pHLIP® platform technology and pHLIP® therapeutics.
The pHLIP-LNP delivery platform technology holds tremendous potential for further unlocking the promise of the medical uses of RNA, DNA and CRISPR therapeutics.
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