Southern Research has been awarded a seven-year contract of up to $22 million to support research that could contribute to the cure of HIV disease. Under this contract, Southern Research will develop and standardize assays that quantitate latent reservoirs of HIV.
"This is a revolutionary area in HIV research that is opening up new avenues for us in infectious diseases," said Southern Research President and CEO Art Tipton, Ph.D. "It supports our 24-year legacy in HIV drug discovery and development for government and pharmaceutical clients."
HIV replication can be effectively suppressed in infected patients with antiretroviral therapy (ART), which reduces the level of HIV in the blood to an undetectable level. However, HIV remains a chronic infection due to its ability to stay hidden within these infected blood cells – latent reservoirs ¬– that are invisible to the body's immune defenses and are not sensitive to anti-HIV drugs. When a latently infected cell is reactivated the cell begins to produce HIV again.
In order to support the HIV cure initiative, Southern Research was awarded the National Institute of Allergy and Infectious Diseases (NIAID) contract HHSN272201500017C, "Quantitative Viral Outgrowth Assay (QVOA) Service Resource." The QVOA is the current best assay for characterizing the latent viral reservoir. However, the assay is not available to many laboratories conducting HIV cure research because it is expensive and labor intensive. Southern Research will expand access to the QVOA and support future clinical research focused on eliminating the latent viral reservoir.
In addition to providing the QVOA as a service resource, Southern Research will work with experts in the field of HIV latency and cure research to develop alternative assays that are more sensitive, less costly, can be completed more rapidly, and require smaller amounts of blood than QVOA. Southern Research will also provide training in the performance of the QVOA to investigators interested in running the assay in their laboratories.
"Our team is excited and energized to be partnering with the HIV research community to enhance our collective understanding of the latent reservoirs of HIV in support of the HIV cure initiative," said Southern Research Director, Infectious Disease Research and Principal Investigator for the contract Mike Murray, Ph.D.