Xcelience and Powdersize announced today the addition of the Netzsch Delta Vita media mills, a nanoparticle milling solution, to their arsenal of capabilities. For the first time, one CDMO can provide solutions for a full range of particle size reduction solutions, from milling and micronization through cGMP manufacturing and global clinical supplies packaging and logistics.
Xcelience announced a structured cash investment in Powdersize in July of this year, adding milling and micronization capabilities to its Suite of Services. The addition of the Delta Vita compliments Powdersize’s micronization capability as a primary enabling technology for improving solubility. It provides additional size reduction to nano-scale particles. The Delta Vita is used for wet grinding of batches ranging from 15mL to approximately 60L. This technology allows for ample milling energies (or tip speeds) to generate sub 1µm particles and stabilize them into a suitably formulated solution.
“Most of our formulation projects are BCS class II and need solubilization improvement,” says Derek Hennecke, President and CEO, Xcelience. “We bought into Powdersize and its micronization tools to provide the simplest and most applicable solution. Now with wet bead milling, we can go after the sub 1µm particle size. It is a rare tool and Xcelience is proud to continue to offer novel, useful solutions like this.”
“With the market leading Netzsch Delta Vita media milling equipment, we can tackle some of the most problematic API insolubility problems out there,” adds TJ Higley, Vice President of Business Development for Powdersize. “Nano particles are a cutting edge formulation solution, and with this piece of equipment we can offer a scale-able and regulatory established pathway with the use of wet media milling.”
The Powdersize/Xcelience combination maximizes the potential for API success by creating a smooth client experience from milling and micronization through formulation development to small-scale commercial manufacturing. This combined expertise under one corporate roof allows for maximum cross-collaboration and results in a fluid, efficient pathway that is tailor made for each API.