Lonza and Renova Therapeutics Announce Manufacturing Agreement for Clinical Supply of RT-100 Gene Therapy

• Lonza

Lonza Houston, Inc., a viral gene therapy manufacturing company, and Renova™ Therapeutics, a biopharmaceutical company developing gene therapy treatments for congestive heart failure and other chronic diseases, have entered into a Manufacturing Services Agreement to develop a scalable manufacturing process and produce cGMP-grade RT-100 (Ad5.hAC6) Drug Product for use in Renova's future clinical trials.

This relationship will leverage Lonza's expertise for the development of a cost-effective, scalable and robust suspension culture-based adenovirus manufacturing platform, which is anticipated to enable the production of sufficient material to meet the potential demand for promising gene therapies such as RT-100.

"This agreement with Renova continues to demonstrate Lonza's leadership position in viral vector production," said Andreas Weiler, Ph.D., Head of Emerging Technologies Business Unit for Lonza's Pharma&Biotech segment. "Lonza will utilize our cGMP manufacturing knowledge and world-class quality systems to help Renova develop these promising novel therapeutics for patients as RT-100 is moving toward late-phase clinical trials."

"Lonza's extensive knowledge in viral manufacturing makes them a great partner in our development of further clinical supply of RT-100 for the treatment of congestive heart failure," said Jack W. Reich, Ph.D., CEO and Co-founder of Renova Therapeutics. "This is one of several exciting milestones for Renova [Therapeutics], as we continue our research and development efforts for cardiovascular and metabolic diseases that affect millions of patients worldwide."