Trovagene has entered into an agreement with AstraZeneca to provide Trovera® urine ctDNA biomarker test and services.
The Trovera® EGFR urine liquid biopsy test will initially be used in an open label prospective biomarker study evaluating whether the combined use of noninvasive testing (urine and blood testing) is as effective as tissue testing in identifying epidermal growth factor receptor (EGFR) T790M mutation status.
"We're pleased to partner with AstraZeneca and to have our urine liquid biopsy test included in a trial designed to explore new and non-invasive ways to detect if patients have this EGFR mutation and may be appropriate for specific treatment options," said Bill Welch, Chief Executive Officer of Trovagene. "This agreement marks a major milestone for Trovagene."
Trovagene performs CLIA laboratory testing services for other biopharmaceutical companies and clinical research third parties. This expertise is supportive of the development of biomarkers for Trovagene's internal drug development program for PCM-075, a polo-like kinase 1 (PLK1) inhibitor. Trovagene plans to use an acute myeloid leukemia (AML) genetic panel to assess patient response to PCM-075 in its phase 1/2 trial.