LineaRx has shipped multiple customized linear DNA amplicons to Evotec SE, a therapeutic development company, to support their research efforts related to neurodegenerative diseases such as Huntington’s, Parkinson’s or Alzheimer’s disease. DNA amplicons are segments of DNA that can serve as templates to generate the RNA or more DNA necessary for nucleic acid-based therapies.
“LineaRx collaborated closely with the customer on the design, production and post processing of their unique amplicon specifications,” said Dr. James Hayward, president and CEO of LineaRx. “Evotec SE, like a growing number of other cutting-edge biotech companies, sees value in evaluating linear DNA as a foundation for their research and recognizes the strengths of LineaRx in the design and large-scale production of linear DNA using LineaRx’s proprietary platform for DNA production by polymerase chain reaction (“PCR”). The amplicons will be evaluated by Evotec SE over the next few months.”
Our shipment to Evotec SE, in support of neurodegenerative disease therapy research, is representative of a growing number of therapy developers coming to LineaRx and placing research quantity orders to evaluate the benefits of linear DNA in their therapeutic development pipeline. Many of the disease targets would have been considered unapproachable by gene therapies only a short time ago.
“Our expertise in PCR, as well as our pathway to cGMP large scale production, makes LineaRx a valuable partner to those companies pursuing a plasmid-free path,” said Brian Viscount, Director of LineaRx. “We continue to see growing demand for linear DNA, in both double-stranded and single-stranded formats, across a wide variety of nucleic acid-based therapies. We have the research bandwidth and production capacity to respond to the increasing demand we are seeing.”