MedPharm has expanded its innovative testing models to support pharmaceutical development programs targeting Coronavirus treatments. These models allow companies to assess therapeutic effectiveness in nasal, airway (bronchial), and deep lung (alveolar) epithelia against members of the Coronaviridae family. The work will help to de-risk development programs and screen drugs for therapeutic effectiveness to accelerate development prior to clinical trials.
“This new model allows companies to screen compounds and formulations to answer critical questions about effectiveness against viral infections in the Coronaviridae family prior to the clinic,” Dr. Jon Lenn, MedPharm’s Chief Technology Officer said. “Finding effective new treatments quickly for these viral infections is imperative in these extraordinary times.”
MedPharm’s facility in North Carolina, US has a dedicated innovation laboratory, able to rapidly support the development of new types of in vitro pharmacodynamic/infection models. The dedicated microbiology lab has been specifically designed with negative internal pressure and biological safety cabinets suitable for BSL2 work. These models are based on air liquid interface tissue culture of primary human cells from different regions of the respiratory system which are then infected with relevant corona viral strains.