Relaxera Pharmazeutische Gesellschaft mbH & Co. KG and CBL Patras (Chemical and Biopharmaceutical Laboratories) announce the signing of an exclusive contract for human relaxin-2.
This cooperation agreement designates CBL as the exclusive manufacturing partner for synthetic human relaxin-2 (GMP and non-GMP) and Relaxera as the exclusive sales executive partner for relaxin.
Relaxera currently undertakes research to characterize synthetic human relaxin-2 as a pharmaceutical candidate for HFpEF (Heart Failure with preserved Ejection Fraction), based on relaxin’s pleiotropic effects. The background is summarized by Thomas Bernd Dschietzig in Mol. Cell. Endocrinol. (2019): “Relaxin-2 for heart failure with preserved ejection fraction (HFpEF): Rationale for future clinical trials”.
Relaxin-2 produced at CBL in Patras will further be used to study the effects of relaxin-2 on myocardial fibrosis as well as the mechanism how relaxin-2 protects pancreatic beta cells and might be beneficial for the treatment of impaired glucose tolerance. Relaxin-2 may also become pharmaceutical relevant in the field of dermatology.
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“Solving the manufacturing requirements for a pharmaceutical drug candidate is one key element in the development of an active pharmaceutical ingredient”, said Prof. Dr. Thomas Bernd Dschietzig, Relaxera’s CEO, “Beyond this, it opens an easier access for continued research in the ‘relaxin community’ worldwide”. And Prof. Dr. Kleomenis Barlos, Founder and President of CBL Patras, agrees “We are experienced in peptide material manufacturing and in commercial applications. We are looking forward to this promising cooperation.”