Charles River Laboratories International, Inc. (NYSE: CRL) and ATEM Structural Discovery (ATEM) announced the formation of a strategic partnership to provide clients access to ATEM’s cryo-electron microscopy (cryo-EM) service solutions. Cryo-EM is a technique that determines the 3D structures of proteins and is utilized to identify how proteins function, how they malfunction in disease and the most effective way to target them with therapies.
ATEM’s leading platform integrates highly optimized biochemistry, hardware, and software to provide in-depth structural insights about challenging targets at a commercial scale. ATEM’s technology directly images vitrified biological macromolecules in single-particle experiments at high resolution. Subsequently, reconstructed coulomb potential maps then allow the precise modeling of 3D atomic coordinates that elucidate the target structure. This leads to the identification of novel distinct binding sites and significantly improves the discovery of drug candidates.
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