RION, a commercial and clinical-stage regenerative medicine company pioneering platelet-derived exosomes for both human and animal health applications, has announced a collaboration with Lonza, to provide cGMP manufacturing and technical support for commercial scale production of its Purified Exosome Product™ (PEP™) drug substance for late phase clinical supply and beyond.
RION developed a proprietary biomanufacturing platform enabling scaled production of platelet-derived exosomes. This platform allows for the advancement of RION’s pipeline of exosome-based therapeutics across multiple indications. Under the terms of the agreement, Lonza will manufacture PEP™ drug substance at its manufacturing facility in Houston (US). RION will leverage Lonza’s world-leading, state-of-the-art extracellular vesicles expertise and capabilities to operationalize its process at scale.
PEP™ is an exosome-based therapeutic platform candidate with immunomodulatory, anti-inflammatory and tissue regenerative properties, formulated as a shelf-stable lyophilized powder. Stabilized regenerative exosomes promote tissue repair and can be administered through multiple routes, enabling use across a broad set of indications. RION is advancing clinical programs in advanced tissue regeneration, immune-mediated dermatology diseases, musculoskeletal disease, pulmonary disease, cardiovascular health and women’s health.