This third article in a series on genotoxic/mutagenic impurities (GTIs)
will discuss the challenges facing synthetic and analytical chemists
as they endeavor to identify and ultimately control levels of these
GTIs or PGIs (potentially genotoxic ...
Sunday, September 16, 2012
This second article on genotoxic / mutagenic impurities (GTIs) will focus on toxicological aspects and discuss in more detail some of the themes mentioned in the first part of the series [1]. The current [2,3] and evolving guidance [4] is based on a ...
This series of articles is intended to provide a general overview of the issues surrounding genotoxic impurities (GTIs) and their potential resolution. Part 1 will focus on general and regulatory aspects, part 2 will review toxicological issues, ...