VectorB2B offers both CDMO and CRO activities for small and large molecules, covering the entire supply chain from early discovery to clinical study in a smooth and efficient process. In addition to our internal teams, VectorB2B also relies on a trusted network of renowned academic institutions and pharmaceutical companies within Portugal’s health sector. VectorB2B is the one-stop shop for your needs in Discovery, Toxicology, CMC and Clinical trials.

VectorB2B services span multiple therapeutic areas and classes of molecules, offering the scientific expertise and technical capabilities required to support your projects from target identification all the way through IND submission. 

Our scientific team connects the expertise of top Portuguese scientists and industry players, providing the best services. Moreover, you can expect frequent, proactive communication from a dedicated project manager from your initial contact and through every milestone of your project.

We provide a fully flexible and tailored solution to meet your needs. In fact, VectorB2B can provide stand-alone or fully integrated support projects to advance your product to the market. The client retains all intellectual property.

Drug Discovery Services

Hit to lead 

• High throughput screening 

• Gene expression profiling

• Gene manipulation

• In vitro target validation

• In vivo target validation

• Molecular Biophysics

• Cellular and Tissue Biophysics 

• Phage display services 

• CellectAb Platform 

Lead optimization and characterization 

•  In vitro efficacy tests using primary cell cultures, cell lines, tissue cultures and injury models

Candidate pharmacology validation

• In vivo efficacy tests in rodent and companion animal models

Toxicology Services

Genetic Toxicology (GLP and non-GLP)

• Ames test 

• In Vitro micronucleus test

• In Vivo micronucleus test

• In Vitro cytotoxicity test

General Toxicology (GLP and non-GLP)

• Maximum tolerated dose

• Dose range finding

• Acute (single dose) toxicity study

• Sub-acute (7- 28 days) repeated dose toxicity studies

• Sub-chronic (90 days) repeated dose toxicity study

• Chronic toxicity study (CT)

Safety Pharmacology

Non-Clinical Safety

Ex-vivo

Toxicokinetics

GMP Manufacturing 

We generate solutions to all stages of development: from gram scale to commercialization for both small and large molecules. 

Small Molecules

• Custom synthesis

• Route scouting

• Process and methods development

• QbD and validation

• Formulation development

• Analytical methods development and validation

• ICH stability

• Clinical trials supply (DS and DP)

• Scale-up

• Tech transfer

• Commercial manufacturing (DS and DP)

• Fill & finish

• Packaging

• Lyophilization

• Regulatory support & Registration

Biologics

Bacteriophages, Recombinant Proteins, Antibodies

• Process development from lab scale to GMP manufacturing

• Microbial expression (BSL1 and BSL2, aerobic and anaerobic)

• Cell lines/banks

• Upstream: single-use bioreactors

• Downstream: AKTA platform and TFF technologies

• GMP manufacturing DS and DP

• Quality Control and Quality Assurance

• Analytical methods development and validation

• Fill & Finish (aseptic and non-aseptic)

• Lyophilization

• Storage for R&D and GMP products

• Pre-formulation and Formulation studies 

• Stability studies

• QP batch release

• Scientific & Regulatory Advisory Services

CRO Services

Strategic Consulting

• Clinical Research Roadmap  from preclinical to clinical 

• Clinical Development Consulting

• Regulatory Consulting

• Statistical Consulting

• Clinical Trial Planning & Conduct

Clinical Solutions

• Project Management

• Clinical Study Design

• Site Management & Clinical Monitoring

• TMF/eTMF management

• Trial Monitoring

• Data Management

• Statistics

Medical Writing

• Literature searches

• Regulatory Writing

• Promotional and Educational materials

Medical and Scientific Services

• Early-stage medical advice for patient populations

• Data Review Committees

• Medical Monitoring

Integrated Services

Biotechnology

Pharma

Medical Devices

Cosmetics 

Bacteriophages

VectorB2B has experience in bringing new products into the clinic from initial screening all the way through GMP manufacturing and preclinical studies to an IND. Currently, our CRO internal team is conducting a few clinical trials in Israel and in Europe for innovative biological therapeutics and medical devices.