Novasep, a supplier of services and technologies for the life sciences industry, and McSAF, a French biotech based in Tours, specialized in bioconjugation tools to design innovative and efficient bio drugs for health and diagnostics, announced their successful collaboration for the preclinical production of ADCITMER®, a next-generation ADC to treat neuroendocrine cancers.
Novasep performed a proof-of-concept study of McSAF’s bioconjugation technology through the production of the ADC at its state-of-the-art bioconjugation unit at its Le Mans site, in France.
This site, which now has more than 15 years of experience in supporting ADC drug innovators, leveraged its specific expertise and purpose-built capabilities to support McSAF’s preclinical studies underway in Merkel cell carcinoma, a rare and aggressive skin cancer, a type of neuroendocrine cancer. Novasep successfully implemented and adjusted the ADC’s laboratory process in its own R&D facilities. The feasibility of process has now been confirmed with a 1st “POC” (Proof of Concept) batch at 600mg scale. This first step of ADCITMER®’s development is currently being supported by France’s Centre-Val de Loire region through a collaborative program between the University of Tours and McSAF (ARD-CVL Biomédicaments).
“The process transfer of our proprietary bioconjugation technology, McSAF Inside®, to Novasep is a huge step in McSAF's story and is a validation of the manufacturing process for our future product developments. Now, with this pilot batch, we will be able to illustrate further the therapeutic relevance of our ADC for metastatic Merkel cell carcinoma patients currently with unmet medical needs.” said Pr Marie-Claude Viaud-Massuard, Chief Scientific Officer of McSAF
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